The Genome Research Center for Hematopoietic Diseases (GRCHD) is funded by the government, Ministry of Health and Welfare (MOHW), Korea and is one of twelve disease based genome research centers designated by MOHW. The center’s main interest is to understand the molecular events and its players in the pathogenesis of leukemic diseases. In recent years researchers around the world have contributed toward the completion of human genome map. In addition, knowledge on proteome and disease associated SNP are rapidly growing. However there is increasing need to perform ethnic based, disease oriented genome researches due to considerable human genomic variations among ethnic origins. To address this, the center focuses on sampling and long term preservation of genomic DNA, serum, bone marrow, EBV transformed clones from Korean patients with hematopoietic malignancies, systematic construction of clinical information database, multi dimensional study using cutting edge technologies with collaborating groups in the field. We have five research teams,
1) Informatics and genetic association studies team led by Prof. HJ Kim,
2) DNA chip based expression profiling studies team led by Prof. TS Kim(Korea University),
3) Leukemia proteome studies team led by Dr SY Cho (Chung-Ang University),
4) Diagnostics and novel treatment development studies team led by DW Kim (Catholic University Medical School).
The center nearing its first stage of 10 year research term is generating the momentum to achieve the goal Providing better quality of life to the patient and family suffering from leukemia with better diagnostics and treatment.

History

- 2001.11. Designated as Genome Research Center for Hematopoietic Diseases by Ministry of Health and Welfare (MOHW), Korea

- 2002.11. Opened at the 7th floor of 3rd building of Chonnam National University Hospital, Hakdong Kwangju, Korea

- 2004.04. Moved in 3rd floor of newly built Hwasoon Chonnam National University Hospital

Organization

- Genome Research Center for Hematopoietic Diseases

- Participating Research Labs

Outcomes

- Building bank of Clinical samples; DNA, RNA, serums from more than 400 cases of patients and 1425 healthy control

- 90 EBV transformed cell lines established and were donated to CDC (Central Genome Center)

- Construction of clinical information database and network with KNIH

- Association studies with 20 genes which are involved in pathogenesis of hematopoietic malignancies

Patents

- Kim Tae Sung , Kim Hyeoung Joon, Cho Won Jye. Pharmaceutical Composition for the Treatment of Leukemia with Reduced Side Effect. KoreaPatent10-2008-0010808(filedon20080201)

- Hwang Seung Yong, Kim Seung Jun, Lee Chang Hyeon, Kim Ji Hoon, Kim Tae Sung, Kim Hyeoung Joon, Song Ju Han, Lee Il Kwon. Deriving Method of Indicator Gene for Discerning Leukemia Subclasses and Indicator Gene and DNA chip Using The Same. KoreaPatent10-2006-0111809(filedon20061113)

Books

- 2001. Search For The Nobel Prize in Physiology or Medicine 1985-2000. Co-authorship. (Chonnam National University Press)

- 2002. Stem Cells in Medicine. P62-75.(Chonnam National University Press)

- 2005 Molecular Oncology. P150-156. (Chonnam National University Press)

- 2006. Hematology. Co-authorship. (E-PUBLIC)

- 2012. Myelodysplastic Syndrome Q & A(ELSEVIER)

Award

- Lylly Investigator Award of Korean Society of the Cancer (2001)

- Investigator Award of Korean Society of the Hematology (2003)

- Investigator Award of Connam National Medical Schol (2005)

- Reward of Commemorative Centennial Ceremony, Chonnam National University Hospital(2010)

- 2010 Award of Health Industry Technology, Ministry of Health and Welfare(2010)

- Academy Award of The Korean Society of Blood and Marrow Transplantation(2013)

Major research tools and instruments

01. Automatic Sequencer (ABI 3100)

02. High-throughput SNP genotyping system (Luminex-100)

03. Melter (HR-1)

04. Microarray scanner

05. Deep freezers

06. Electrophoresis units

07. Ultra large scale liquid nitrogen tanks

08. Multidimensional liquid chromatography (MDLC)

09. Centrifuges (refrigerated, ambient temperature)

10. Digital image documentation

11. PCR machines (Real time, general purpose)

12. Microplate fluorescence reader

13. CO2

14. incubators

15. Automated Magnetic Cell Sorter

16. Dual bay thermal Cycler

17. DNA Amplification System

18. Bio Photometer

19. Takara Dice Gradient PCR

20. Liquid handling system

21. Chemiluminescence and fluorescenceimae Analyser

22. TissueLyser

23. Research Inverted Fluorescence Microscope & Top quality Microscope Cooled Digital imaging system

24. Rotor-Gene 62H0